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ANTIPYRINE. 291 :

lumbago. A painless injection may be made by half-filling a
hypodermic syringe with a fifty per cent, solution of antipyrine,
which will amount to about five and a half grains ; then immerse
the syringe into a ten per cent, solution of cocaine, drawing up
enough of the cocaine into the syringe to make it about three-
fourths full ; this will amount to one-third grain of cocaine.
The two solutions readily mix and do not decompose, and may
be used as a local anaesthetic.
Dental Uses.—Antipyrine is used hypodermically with great
success in cases of severe neuralgia of the fifth pair of nerves.
Also, in cases of acute pericemental irritation, and in reflex
neuroses of dental origin it has given great relief. Fifteen grains
in half an ounce of water have given relief in a case of perice-
mentitis, ceasing in twenty minutes with no return of the pain
but many prefer antifebrin (acetanilide) as being safer than anti-
pyrine. It also has a marked effect in controlling hemorrhage
from the gums and alveolar cavities when used as a hemostatic
after the extraction of teeth. Prof. G. Cesari claims that anti-
pyrine more or less speedily arrests hemorrhage from both large
and small blood vessels when applied in solutions of not less than
forty, or, better, fifty per cent. The solution as well as the
powder should be applied on pledgets of cotton wool. Antipy-
rine has also been administered internally with satisfactory results
in the treatment of periodontitis ; and in cases where, owing to
the severity of the symptoms in the same affection, the internal
administration has proven unsuccessful, the hypodermic injection
of fifteen grains has afforded relief; or the hypodermic injection
followed in one half hour by the internal administration of fifteen
grains of the drug will afford relief in cases of acute periodontitis.
Antipyrine has been successfully used for arresting hemorrhage
after the extraction of teeth, as it has none of the disagreeable
effects of perchloride of iron. It is applied on cotton.
For Nervous Cases.
R . Antipyrine gr.xviij
Aq. destillat q.s. ad ft. sol.
Ft. sol et adde
Acidi valerianici gtt.xv.
Shake well and stand aside to allow salt to crystallize.