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290 DENTAL MEDICINE.

^"1^. Doveri ....
Anodoyne and Analgesic. grs. viii
Soda bicarb grs. xij.
R. Antikainnia ... ••
tt.
"^
i
rt. viij capsules.
^ '^ aa^ss y^^ ^ r\ i i
Quinia sulph
^
DObE.—One capsule every 4 hours.
ANTIPYRINE—DIMETHYLOXYQUINIZINE.
Formula.—CuHjjNgO.
Antipyrine in is the form of whitish or grayish-white crystal-
line powder, slightly-bitter sweetish taste, and soluble in water.
It combines with acids to form salts.
Medical Properties and Therapeutic Uses.—Antipyrine is a
powerful antipyretic, local anaesthetic, disinfectant, hemostatic
and stomachic tonic, and acts as an antiseptic in preventing
fermentative changes in the intestines. It is also slightly hyp-
notic. It stimulates the secretions and readily diffuses into the
blood. It first stimulates and then paralyzes the nerve-centres,
dilates the cutaneous vessels, and increases the loss of heat by
radiation, reducing the temperature rapidly. Sometimes it may
cause dangerous symptoms, such as a feeble pulse, profuse dia-
phoresis and collapse. It is employed in typhoid and malarial
fevers, pneumonia, phthisis, neuritis, sciatica, locomotor ataxis,
neuralgia of the fifth pair of nerves associated with neuritis and
sciatica, migraine, acute rheumatism, epilepsy, chorea, etc., and
as a substitute for morphine, and in the morphine habit.
Its administration is soon followed by profuse perspiration,
coldness of the surface, slowed pulse, depression, and if fever is
present by lowered temperature within a half hour after taking
the drug. In health its use may cause slight nausea, singing in
the ears, and a slight decrease in the temperature of the body. It
has no efi^ect upon respiration, but acts as a sedative upon the
brain. It is eliminated by the kidneys, appearing in the urine
about three hours after ingestion.
Dose.—Grs. v to grs. Ix, being determined by its uses. Sub-
is very effective in painful affections orig-
cutaneously injected, it
inating in the nerves.
The hypodermic use of antipyrine has given very satisfactory
results in the treatment of nervous articular and muscular pains,
gastric affections, bronchial asthma, articular rheumatism, chronic