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PATHOGENIC BACTERIA OF THE HUMAN MOUTH. 267

guinea-pigs, rabbits, and mice, althougli not constantly. Often
also two ditierent forms of disease are caused hy it.
" Rabbits frequently perished after fifteen to twenty days,
showing symptoms of chronic septicfemia,—increase of tempera-
ture, general debilitj-, gradual emaciation, etc. At the point of
infection nothing characteristic was found, sometimes only a cir-
cumscribed infiltration with suppurating center; the internal
organs revealed intense anaemia ; the blood and the organic juices
contained but few cocci, which were usually arranged in short
chains. Inoculations with the blood of the diseased animals were
without result.
" In guinea-pigs and mice which had been subcutaneously in-
jected with saliva, pus formed at the point of vaccination, and
had the tendency to spread into the subcutaneous connective and
muscular tissues. Guinea-pigs often survived this suppuration,
mice generally died.
" Infections with pure cultures of this Imcterium also had the
same effect.
" This streptococcus cannot be distinguished from that of
erysipelas, phlegmon, and puerperal metritis. Their colonies
have the same appearances, their development is equally, slow,
and the results of experiments made with them on animals are
identical."
Vaccination on the scarified ear of rabbits usually led to the
characteristic symptoms of erysipelas.

h. Staphylococcus salkarias pyogenes.
Staphylococcus salivarius pyogenes was likewise observed but
once, in the contents of an abscess of a guinea-pig which had
been inoculated with the saliva of an individual suifering from
angina scarlatina. It was cultivated in milk, bouillon, blood-
serum, agar-agar, potato, beef-water and wheat-infusion gela-
tine. The latter was liquefied. Milk was precipitated in large
flakes. In twenty-four hours bouillon at 37° C. became very
cloudy, afterward the growth was precipitated as a white,
dense deposit. This micro-organism is easily obtained in pure
culture from the contents of such abscesses, by making the usual
cultures from a drop of pus. Cultivated on gelatine at room