Page 513 - My FlipBook
P. 513
PHENATE OF COCAINE. 51 1
it exerts a stimulating effect on the heart, and that in doses of
ten grains and upward, a sedative effect is produced in addition
to its analgesic actions on the sensory apparatus of the nervous
system.
The stimulating effect of the ammonia constituent is first per-
ceived, and this is soon followed by a soothing sensation, due to
the gradual subsidence of the painful manifestations. It has no
toxic properties.
Therapeutic Uses.—It is claimed for phenalgin that it is hyp-
notic, anodyne, analgesic, antipyretic, antiperiodic. It is em-
ployed in all painful affections, such as neuralgia, rheumatism,
gastralgia, painful menstruation, headache, effects of dissipation,
migraine, influenza, insomnia, etc., for its anodyne and hypnotic
properties.
Dose.—Of phenalgin, gr. v to xx. It is administered in the
form of tablets or in powder.
Dental Uses.— Phenalgin is serviceable in facial neuralgia, es-
pecially in neuralgias of the fifth nerve, the pain of periodontitis,
and alveolar abscess, pulpitis. Dr. A. S. Atkinson states that
permanent relief from painful alveolar abscess of two weeks'
standing was obtained within one hour after prescribing phenal-
gin.
PHENATE OF COCAINE—CARBOLATE OF COACINE.
Derivation.—Phenate of cocaine, as prepared by Merck, is, as
its name implies, a combination of carbolic acid and cocaine
containing seventy-five per cent, of the cocaine alkaloid. It is a
slightly colored substance, of the consistence of thick honey, and
possesses both antiseptic and anaesthetic properties. Hydro-
chlorate of cocaine is open to the serious objection that when
applied to cut surfaces it causes dangerous systemic effects en-
dangering the life of the patient, and has in a limited number of
cases, it is asserted, caused death. The phenate of cocaine, on
the other hand, containing the alkaloid, is not so prone to cause
symptoms of cocaine poisoning or any bad after-effect. It is sol-
uble in alcohol of from thirty to fifty per cent., such a solution
possessing a faint odor of carbolic acid.
