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402 DENTAL MEDICINE.

EUGENOl ACETAMID.
Eugenol-acetamid is prepared as follows : Monochloracetic
acid is acted upon by eugenol sodium, when eugenol acetic acid
results. This acid is treated with alcohol and hydrochloric acid,
by which it is converted into the " ethylester of eugenol-acetic
acid. Strong alcoholic ammonia converts this into eugenol-
acetamid. As crystallized from water it occurs in lustrous
scales; from alcohol in fine needles ; melting at iio°."
Therapeutic and Dental Uses.— It is claimed for eugenol-
acetamid, that when it is applied in the form of a fine powder,
it produces local anaesthesia without any caustic action, similar to
cocaine. It has been successfully employed as a local anaesthetic
in the treatment of wounds ; and is also recommended as an
obtundent in the extraction of teeth.

EUROPHEN—ISOBUTYL-ORTHO-CRESOL-IODIDE.
Derivation.—Europhen is obtained by the action of isobutyl-
alcohol upon elevated temperature, producing isobutylcresol. This is then
acted upon by iodine in potassium iodide, the resulting iodine
compound being isobutylorthocresoliodide or europhen. Euro-
phen is an amorphous yellow precipitate, which is separated by
filtration and cleansed by washing, and afterward dried in the
dark at ordinary temperature.
The percentage of iodine in europhen is about 27.6, which
corresponds accurately with a proportion of one atom of iodine
to two molecules of isobutylcresol, Europhen is resinous to the
touch, and when applied to the mucous membrane or to the skin,
adheres tenaciously. It possesses an aromatic odor, which, how-
ever, disappears when it is made into a solution or mixture. It
is insoluble in glycerine or water, but readily soluble in alcohol
(30 per cent.), ether or chloroform (equal weight), and such com-
pounds of these agents as collodion, and liquid gutta percha, and
also in fatty oils. A 25 per cent, solution of europhen can be
made by rubbing it at a low temperature in olive oil, which,
after being filtered, remains clear for a long period. In contact