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DEPOSITS OF CALCOGLOBULIN. 861
these there are generally a number of small globular forms, many of which
have the onion-like layers of the calcospherite quite distinctly marked.
In Fig. 456 I give an illustration of one of these masses as it occurred
in the pulp of a second molar
Fig. 456. from the mouth of a girl of
fifteen years. About one-half
of the coronal portion of the
pulp was involved in inflam-
mation, which, from the his-
tory of the case, must have
been present for as much as
two months, the tooth re-
maining quiet most of the
time, but subject to par-
^^^^«iP^ oxysms of pain lasting from
a few moments to two or
Deposit of Calcoglobulin within the Tissues of an three hours. There were sev-
Inflaiued Pulp.
eral such masses as the one
represented in the pulp-tissue, all lying a little inside of the odontoblast
layer and having globular forms in their mass or attached to their mar-
gins. In one part of the pulp there were a number of detached globules
similar to those attached to the specimen shown. When mounted in
glycerin, without staining, these masses are very transparent and show
no color whatever. They stain an intense red with fuchsin, and are not
bleached by immersion in alcohol for five or six hours. With hsema-
toxylin they are stained blue or purple. Judging from the forms pre-
sented by these bodies, I suppose them to be calcoglobulin : I have not
made the chemical examination that would be required to demonstrate
this. They are entirely different from lymph-deposits, and do not
show the reactions peculiar to amyloid deposits.
The idea that calcoglobulin is deposited in the pulps of teeth in the
soft state has been arrived at with some difficulty, from the fact that it
was known only as the basis of the pulp-uodule, the calcospherite^ and
perhaps of the dentine and bones, which remained after the solution of
the lime salts with which it was originally combined. It thus forms
the matrix of these bodies, and the assumption that this is calcoglobulin
necessarily embraces the idea that the basis substance may be formed in
the absence of sufficient lime salts for the complete calcification of the
matrix. I know of no record of the accomplishment of this by arti-
ficial means, and certainly the subject needs further investigation.
The only situations of the natural—or, I might say, the pathological
formation of the calcospherite is in the dental pulp and in varicose veins.
The formation of these bodies artificially seems to require the presence
in solution of albumen, the salts of lime, and carbonic acid (carbon
dioxide). When these materials are brought together in a tightly-stop-
pered bottle, calcospherites closely resembling those found in the dental
pulp and in varicose veins are slowly deposited at the bottom. This
subject has been very closely investigated by Rainie, Ord, Harting, and
others, and the identity of the artificial forms with those found in the
situations named seems well established. Now, the fact that these
DEPOSITS OF CALCOGLOBULIN. 861
these there are generally a number of small globular forms, many of which
have the onion-like layers of the calcospherite quite distinctly marked.
In Fig. 456 I give an illustration of one of these masses as it occurred
in the pulp of a second molar
Fig. 456. from the mouth of a girl of
fifteen years. About one-half
of the coronal portion of the
pulp was involved in inflam-
mation, which, from the his-
tory of the case, must have
been present for as much as
two months, the tooth re-
maining quiet most of the
time, but subject to par-
^^^^«iP^ oxysms of pain lasting from
a few moments to two or
Deposit of Calcoglobulin within the Tissues of an three hours. There were sev-
Inflaiued Pulp.
eral such masses as the one
represented in the pulp-tissue, all lying a little inside of the odontoblast
layer and having globular forms in their mass or attached to their mar-
gins. In one part of the pulp there were a number of detached globules
similar to those attached to the specimen shown. When mounted in
glycerin, without staining, these masses are very transparent and show
no color whatever. They stain an intense red with fuchsin, and are not
bleached by immersion in alcohol for five or six hours. With hsema-
toxylin they are stained blue or purple. Judging from the forms pre-
sented by these bodies, I suppose them to be calcoglobulin : I have not
made the chemical examination that would be required to demonstrate
this. They are entirely different from lymph-deposits, and do not
show the reactions peculiar to amyloid deposits.
The idea that calcoglobulin is deposited in the pulps of teeth in the
soft state has been arrived at with some difficulty, from the fact that it
was known only as the basis of the pulp-uodule, the calcospherite^ and
perhaps of the dentine and bones, which remained after the solution of
the lime salts with which it was originally combined. It thus forms
the matrix of these bodies, and the assumption that this is calcoglobulin
necessarily embraces the idea that the basis substance may be formed in
the absence of sufficient lime salts for the complete calcification of the
matrix. I know of no record of the accomplishment of this by arti-
ficial means, and certainly the subject needs further investigation.
The only situations of the natural—or, I might say, the pathological
formation of the calcospherite is in the dental pulp and in varicose veins.
The formation of these bodies artificially seems to require the presence
in solution of albumen, the salts of lime, and carbonic acid (carbon
dioxide). When these materials are brought together in a tightly-stop-
pered bottle, calcospherites closely resembling those found in the dental
pulp and in varicose veins are slowly deposited at the bottom. This
subject has been very closely investigated by Rainie, Ord, Harting, and
others, and the identity of the artificial forms with those found in the
situations named seems well established. Now, the fact that these
